Endocrine Abstracts

Introduction: Type 2 diabetes is one of the main risk factors for severe COVID 19 infection. Inadequate glycemic control is related to high inflammation, hypercoagulability, and mortality in COVID-19 patients. Glucose lowering medications commonly used to treat diabetes mellitus (DM) might have effects on COVID 19 pathogenesis. Overall, evidence is conflicting as to which glucose-lowering drugs are associated with the most favourable outcomes in patients with COVID-19. The aim...

Introduction: IDegLira is the first fixed ratio combination of a basal insulin degludec and a glucagon-like peptide-receptor analogue liraglutide. These combination producereduction in glycated hemoglobin A1c (HbA1c) and help to mitigate the weight gain. The aim of this study was to evaluate relationship between change in glycemic parameters and body weight in patients who began therapy with IDegLira.Patients and Methods: Retrospective study included 86 ...

Background and aims: Obesity can be cause because of reduction in energy expenditure and /or increased caloric intake. Total calorie intake has increased in recent decades and studies on eating behavior have reported increased intake of foods rich in fats and sugars. Many regulatory pathways for food intake, including those that use serotonin as a neurotransmitter, are affected by obesity or by hypercaloric diets. Summarizing the data known so far, it can be said that reduced ...

Background: Bone mineral density measurement sometimes reveals osteoporosis that is a consequence of undiagnosed or neglected long-standing health disorders. These secondary causes of osteoporosis should be carefully investigated, especially in men.Case Presentation: A 63-year-old male complained of back pain and was referred to endocrinology clinic due to a poor densitometry finding indicating osteoporosis. He presented with severe obesity (body mass in...

Bone metabolism disorders in hemodialysed patients (HD) involve several humoral factors, of which PTH plays the central role. Leptin is a protein hormon secreted by the adipocytes and related to malnutrition, anemia and bone metabolism disorders in chronic kidney disease patients. The aim of the study was to was to evaluate serum leptin levels and bone metabolism in chronic HD patients depending on body mass index (BMI). This cross section study included 93 HD patients distrib...

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. The aim of this study was to assess the impact of insulin-induced hypoglycemia on the platelet activity, endothelial dysfunction and the physiological anticoagulant level in patients with DM1.Research design and methods: We studied seve...

It was suggested that polycystic ovary syndrome (PCOS) patients have an increased risk for autoimmune thyroid disease. However the mechanisms underlying this association are incompletely clarified. The aim of the present study is to evaluate the factors associated with thyroid autoimmunity in patients with PCOS. We performed a retrospective study which included 126 PCOS patients (mean age 24±4.5 years, mean body mass index, BMI 27±7.33 kg/sqm) diagnosed based on Rott...

Background and aims: Although 95% of serotonin is produced in the periphery, its functions have been ignored until now. Recently it became clear that theserotonin system in the periphery regulates multiple physiological aspects independently of the brain-derived serotonin. In particular, peripheral serotonin playsa pivotal function in the regulation of glucose and lipid homeostasis by acting on different organs and cell types. Serotonin produced in pancreatic b- cellspromotes ...

Sixteen percent of parathyroid adenomas can be situated in an ectopic location. Ectopic parathyroid glands result from aberrant migration during early stages of development, and lack of successful identification may lead to lack of success in parathyroid surgery. These glands are most frequently found in the anterior mediastinum, in association with the thymus or the thyroid gland. Ectopic parathyroid glands are a major cause of persistent and recurrent hyperparathyroidism.</p...

Background and aims95% of serotonin is produced in the periphery. Serotonin system in the periphery regulates multiple physiological aspects. In previous researches that we made, using the Tph1 inhibitor - LP533401 (peripheral serotonin inhibitor) it shows that this agent could be use for treatment of obesity and obesity-induced diabetes in male Wistar rats. With current study we aimed to look more detailed in to fine mechanisms of action of serotonin re...